Like the previous versions, the database of Desktop Defender 2010 has been ripped from Clam AntiVirus (ClamAV), an open source (GPL) and free anti-virus toolkit.
HijackThis symptoms:
O2 - BHO: StatusBarPane - {CCB5551D-8594-4999-85F9-1E3EABCB95AC} - C:\Program Files\Desktop Defender 2010\IEAddon.dllNotice the LSP Hijack: Removing siglsp.dll file without restoring the LSP chain will break Internet connexion.
O4 - HKLM\..\Run: [Desktop Defender 2010] C:\Program Files\Desktop Defender 2010\Desktop Defender 2010.exe
O10 - Unknown file in Winsock LSP: c:\program files\desktop defender 2010\siglsp.dll
O10 - Unknown file in Winsock LSP: c:\program files\desktop defender 2010\siglsp.dll
Leaving it will allow an infected componant to watch the network traffic.
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If your system is infected with Desktop Defender 2010, follow the Bleeping Computer removal guide. MBAM is the only free tool to remove completely Desktop Defender 2010 AND the LSP Hijack.